The network said it would broadcast the segment that Matt Lauer taped with Dottie Sandusky on Wednesday morning.
In excerpts posted online by NBC, Sandusky defends her husband, saying she's sure he didn't "do the horrible crimes that he's convicted of."
“I have known Jerry 38 years, and we’ve been married for 37. We’ve always been truthful with each other. He is not guilty of these horrific crimes that he’s been charged with,” Dottie Sandusky said.
Jerry Sandusky is serving a 30- to 60-year sentence in a maximum-security southwestern Pennsylvania prison. He's maintained his innocence and is awaiting word from the state Supreme Court about whether it'll take his case on appeal.
Dottie Sandusky testified for about 40 minutes for the defense during the 2012 trial that ended in a 45-count conviction.
In the interview, Sandusky also spoke about the changes she has seen in her husband since he’s been in prison.
She said he told a friend he missed family meals and playing with his grandchildren.