Pennsylvania state police say the crash occurred around 2:20 a.m. Thursday in the westbound lanes in Brecknock.
The 25-year-old Brooklyn resident and two other people safely got out of the vehicle when it overturned. A commercial vehicle and another car stopped at the scene to assist.
State police say the tractor-trailer soon hit the overturned vehicle and the other car, and the Brooklyn man was struck and killed.
Authorities say the two other people who had been in the overturned car then fled the scene.
Three other people sustained minor injuries.
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