The local companies that saw the biggest increases, declines in the stock market

PITTSBURGH — Three of Pittsburgh's publicly traded companies — a biotech firm, a manufacturer and a water treatment provider — racked up triple-increases in their stock price over 2019.

Krystal Biotech Inc. (Nasdaq: KRYS) had the biggest increase of all local companies, with a 2019 gain of 171 percent: Krystal Biotech's stock shot up from 20.42 to 55.38. It's a Pittsburgh-based gene therapy company that creates treatments for skin diseases.

Koppers Holdings Inc. (NYSE: KOP), which makes rail ties and other products, saw its stock price rocket 129 percent from 16.70 on 2019’s first trading day of Jan. 2 to 38.22 on the final trading day, Dec. 31. One of Pittsburgh’s newest publicly traded companies, Evoqua Water Technologies Inc. (NYSE: AQUA), had an equally impressive run last year. It was up 101 percent, from $9.44 a share to $18.95.