The Pennsylvania Turnpike was closed eastbound between the New Stanton and Breezewood Interchanges for several hours Wednesday.
[ PHOTOS: Deadly crash backs up traffic for miles on Pennsylvania Turnpike ]
A fatal accident involving two tractor-trailers happened at mile maker 158 around 3 p.m.
According to spokesman for the turnpike, Carl DeFebo, posted on Twitter, one truck went fully over the embankment, while the other only partially left the road surface.
Around 7 p.m., the highway between New Stanton and Bedford was reopened, with the rest following later in the night.
[ We broke this story in our WPXI News app. Download it HERE. ]
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Police believe one of the drivers was passing the other while they went around a corner in the road, and one of the drivers drifted into the other lane, hitting the other truck.