Authorities said a truck hauling brick was trying to make a left turn onto Crawford Avenue from Route 119 when a car slammed into the back of it early Wednesday.
Kenneth Murphy, 37 of Dunbar, was killed in the crash.
Alan Smalley, 21, of Leisenring, and Donald Dean, 23, of Dunbar, suffered moderate injuries, police said.
On Tuesday, David Prah, 22, was killed in a crash at about 11 a.m. on the same stretch of road.
Target 11 discovered that Route 119 in Connellsville is considered one of the most dangers roads in Fayette County.
According to the most recent data available, there have been 87 crashes resulting in two deaths and more than 20 injuries on Route 119 in recent years.
People who live and work in the area said they are well aware of the road's reputation.
"I've actually been in the area for three and a half years and there's been three wrecks just right here," said Aleesha McFadden. "I'm actually kind of scared to drive on the road myself. It's pretty bad. I look both way before I cross the highway here."
The stretch of Route 119 is less than a mile long and has twice the amount of accidents recorded than the second most dangerous road in Fayette County.
Previous Stories: November 30, 2011: Target 11 Investigates Most Dangerous Roads