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After 15 years, Justin Chambers has left ‘Grey’s Anatomy’

One of “Grey’s Anatomy” long-running cast members, Justin Chambers, has left the medical drama after 15 years.

Chambers, who played Alex Karev on the show, left last season after a 15-year run. He leaves only three other actors who have been with the series since the first episode: Ellen Pompeo, James Pickens Jr. and Chandra Wilson.

Chambers’ last episode aired Nov. 14.

Chambers discussed the timing in a statement to Deadline:

“There’s no good time to say goodbye to a show and character that’s defined so much of my life for the past 15 years. For some time now, however, I have hoped to diversify my acting roles and career choices. And, as I turn 50 and am blessed with my remarkable, supportive wife and five wonderful children, now is that time.”

—  Statement to Deadline

The Associated Press contributed to this report.